Charles Hildebolt received a BS and DDS from Ohio State University. He spent 2½ years in the US Army at William Beaumont General Hospital in El Paso, Texas. After having a private dental practice for 9 years in Beavercreek, Ohio, he attended Washington University, where he received a master's degree and PhD in Physical Anthropology. Until the Washington University School of Dental Medicine closed in 1991, he had joint appointments at the Schools of Dental Medicine (Diagnostic Services) and Medicine (Radiology). He is currently a Professor of Radiology Washington University School of Medicine, Adjunct Professor of Anthropology Washington University, Adjunct Clinical Associate Professor Saint Louis University Center of Advanced Dental Education, and biostatistical consultant for Southern Illinois University School of Dental Medicine.

Charles Hildebolt’s long-term goal is to identify treatments that minimize oral bone loss. To achieve this goal, he is investigating new methods for using digital dental radiographic images to obtain oral bone mass measurements. He intends to use these methods for osteoporotic risk assessment, treatment monitoring, and research. With methods that he and his colleagues have developed, they have found that oral bone loss is associated with femoral and vertebral bone loss and that estrogen and/or vitamin D and calcium can reduce this bone loss. He and his colleagues are currently investigating the extent to which increased intakes of vitamin D and calcium improve oral health in adults. The possibility of promoting alveolar bone gain or reducing alveolar bone loss with vitamin D and calcium supplementation could have a significant impact on quality of life by leading to a reduction in surgical treatments aimed at repairing or minimizing alveolar bone damage caused by periodontal disease, a decrease in tooth loss attributable to alveolar bone loss, a decline in the placement of implants or prosthetic devices (bridges and partial dentures) to replace lost teeth, and a reduction in the number of denture remakes and relines required because of alveolar bone resorption. Charles Hildebolt and his colleagues are currently working on a system that uses photostimulable phosphor plates for improved oral-bone measurement in research projects. They are also studying disease induced changes in the microstructure of alveolar bone (that is, the trabecular structure of cancellous bone and the osteon structure of cortical bone). Other areas for which Charles Hildebolt has research interest include morphometric variation in skulls, brains, and teeth of contemporary humans and fossil hominids.

Prefessor Hildebolt is on the editorial boards of Dento Maxillo Facial Radiology (DMFR) and Calcified Tissue International (CTI), is an sub- editor for image guided treatment for Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics (OOOOE), and is an ad hoc reviewer for 14 other journals. He is a grant proposal reviewer for the National Institutes of Health, Whitaker Foundation, United States Army, National Science Foundation, British Columbia Health Care Research Foundation, and Hospital for Sick Children Foundation, Sheffield Hospitals Charitable Trust, Wellcome Trust, and Canadian Institutes of Health Research. He is the Councilor for Educational Affairs on the Executive Council of the American Academy of Oral and Maxillofacial Radiology.

1. Hildebolt CF, Fletcher G, Yokoyama-Crothers N, Conover GL, Vannier MW  A comparison of the response of storage phosphor and film radiography to small variation in X-ray exposure. Dento Maxillo Facial Radiology 26:147-151, 1997.
2. Hildebolt CF:  Osteoporosis and oral bone loss. Dento Maxillo Facial Radiology 26:3-15, 1997.
3. Hildebolt CF, Brunsden B, Yokoyama-Crothers N, Pilgram TK, Townsend KE, Vannier MW, Shrout MK.  Comparison of Reliability of Radiodensity Measures of Alveolar Bone Loss Performed with Manual and Computer Intensive Methods. Dento Maxillo Facial Radiology, 27:245-250, 1998
4. Hildebolt CF, Brunsden B, Yokoyama-Crothers N, Pilgram TK, Townsend KE, Vannier MW, Shrout MK.  Comparison of Reliability of Radiodensity Measures of Alveolar Bone Loss Performed with Manual and Computer Intensive Methods. Dento Maxillo Facial Radiology, 27:245-250, 1998.
5. Hildebolt CF, Pilgram TK, Yokoyama-Crothers N, Fletcher G, Helbig JL, Bartlett TQ, Gravier M, Vannier MW, Shrout MK. Reliability of linear alveolar bone loss measurements of mandibular posterior teeth from digitized bitewing radiographs.  Journal of Clinical Periodontology, 25:850-856, 1998.
6. Pilgram TK, Hildebolt CF, Yokoyama-Crothers N, Dotson M, Cohen S, Hauser J, Kardaris E.  Relationships between radiographic alveolar bone height and probing attachment level:  data from healthy post-menopausal women. Journal of Clinical Periodontology, 27:341-346, 2000.
7. Hildebolt CF, Couture RA, Whiting BR.   Dental photostimulable phosphor radiography.  Dental Clinics of North America. 44:273-297, 2000.
8. Hildebolt CF, Pilgram TK, Yokoyama-Crothers N, Vannier MW, Dotson M, Muckerman J, Hauser J, Cohen S, Kardaris E, Hanes P, Shrout MK, Civitelli R.  Alveolar bone height and postcranial bone minearl density:  negative effects of cigarette smoking and parity J Periodontol, J Periodontol, 71:683-689, 2000.
9. Couture RA and Hildebolt CF.  Quantitative dental radiography with a new photostimulable phosphor system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89:498-508, 2000.
10. Couture RA, Hildebolt CF, “Precise image-receptor calibration and monitoring of beam quality with a step wedge” DentoMaxillofacial Radiology, 31, 56-62, 2002.
11. Pilgram TK, Hildebolt CF, Dotson M, Cohen SC, Hauser, JF, Kardaris E, Civitelli R. Relationships between clinical attachment level and spine and hip bone mineral density: data from healthy postmenopausal women.  J Periodontol, 73(3), 298-301, 2002.
12. Civitelli R., Pilgram TK, Dotson M, Muckerman J, Lewandowski N, Armanmento-Villareal R, Yokoyama-Crothers N, Kardaris E, Hauser J, Cohen S, Hildebolt CF. Hormone/Estrogen Replacement Therapy Improves Alveolar and Postcranial Bone Density In Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Archives of Internal Medicine, 162:1409-1415, 2002.
13. Hildebolt CF, Pilgram TK, Yokoyama-Crothers N, Vannier MW, et al.  The pattern of alveolar crest height change in healthy postmenopausal women after 3 years of hormone/estrogen replacement therapy.  Journal of Periodontol, 73(11), 1279-1284, 2002.
14. Teefey SA, Hildebolt CF, Dehdashti F, Siegel BA, Peters MG, Heiken JP, Brown JJ, McFarland EG, Middleton WD, Balfe DM, and Ritter JH (2003) Detection of primary hepatic malignancy in liver transplant candidates: prospective comparison of CT, MR imaging, US, and PET. Radiology 226:533-42, 2003.
15. Hildebolt CF, Pilgram TK, Dotson M, Armanmento-Villareal R, Hauser J, Cohen S, Kardaris E, Civitelli R.  Estrogen and/or calcium + vitamin D increase mandibular bone mass.  J of Periodontol 75:811-816, 2004.
16. Falk D. Hildebolt CF, Smith K, Morwood MJ, Sutikna T, Brown P, Jatmiko, Saptomo WE, Brunsden B, Prior F. The Brain of LB1, Homo floresiensis.  Science Express, March, 2005 and/or Science 308:242-245, 2005.
17. Hildebolt CF. Effect of vitamin D and Ca on Periodontitis.  Journal of Periodontology. 76:1576-1587, 2005
18. Falk, D., Hildebolt, C., Smith, K., Morwood, M.J., Sutikna, T., Jatmiko, Saptomo W. E., Brunsden, B. & F. Prior. Response to Martin et al.’s Comment: “The Brain of LB1, Homo floresiensis,” Science Online, Science 312: 999, 2006.
19. Siegel MJ, Hildebolt CF, Bae KT, Hong C, White NH. Total and Intraabdominal Fat Distribution in Preadolescents and Adolescents: Measurement with MR Imaging. Radiology 242:846-856, 2007.
20. Falk, D., Hildebolt,C., Smith, K., Morwood, M.J., Sutikna, T., Jatmiko, Saptomo, W.E., Imhof , H., Seidler, H. & Fred Prior. Brain shape in human microcephalics and Homo floresiensis, Proceedings of the National Academy of Science of the United States of America (PNAS)  104: 2513-2518; published online before print as 10.1073/pnas.0609185104, 2007.
21. Saxena MT, Aton SJ, Hildebolt C, Prior JL, Abraham U, Piwnica-Worms D, and Herzog ED.  Bioluminescence imaging of period1 gene expression in utero. Molecular Imaging: Official Journal of the Society for Molecular Imaging 6:68-72, 2007.